Restarting by Design: Agile Crisis Management for Rapid Resumption of Cardiovascular Clinical Trials

Crisis Management for Rapid Resumption of Cardiovascular Clinical Trials during the COVID-19 pandemic

The entire landscape of hospital-based clinical trials dramatically changed when COVID-19 singlehandedly stopped the global recruitment of ongoing cardiovascular trials. Heart failure clinical trials were already subject to factors such as regional variation in clinical practice, trial implementation, and patient characteristics, which drive event rate and treatment effect size assumptions key to demonstrating clinical benefit. […]