Valvular heart disease

Valvular heart disease refers to conditions that affect one or more heart valves, impairing their normal function. Valvular Heart Disease (VHD) represents a significant health concern globally, affecting millions of individuals and posing substantial challenges to healthcare systems. Ongoing efforts in research and clinical care are crucial for advancing our understanding of VHD and improving outcomes for affected individuals worldwide.

SCIRENT, a European-based Contract Research Organization (CRO), specializes in groundbreaking research to advance scientific understanding and improve patient outcomes in valvular heart disease with a specific approach.

Comprehensive overview of Valvular Heart Disease for cardiac researchers

Understanding Valvular Heart Disease

The heart has four valves — the tricuspid, pulmonary, mitral, and aortic valves — that are crucial in regulating blood flow through the heart chambers. Valvular heart disease can damage the valves, causing them to leak (regurgitation) or narrow (stenosis). This dysfunction can disrupt the smooth flow of blood through the heart and may lead to various cardiovascular complications.


Common types of valvular heart disease include:

Aortic Stenosis

Narrowing of the aortic valve, restricting blood flow from the left ventricle to the aorta.

Aortic Regurgitation

Backflow of blood from the aorta to the left ventricle due to a leaky aortic valve

Mitral Stenosis

Narrowing of the mitral valve, limiting blood flow from the left atrium to the left ventricle.

Mitral Regurgitation

Backflow of blood from the left ventricle to the left atrium due to a leaky mitral valve.

Tricuspid Valve Disorders

Conditions affecting the tricuspid valve, such as regurgitation or stenosis.

Pulmonary Valve Disorders

Abnormalities in the pulmonary valve, including stenosis or regurgitation.

Valvular heart disease can be congenital (present at birth) or acquired later in life. Acquired causes may include age-related degeneration, infections (e.g., endocarditis), rheumatic fever, and other heart conditions. The symptoms of valvular heart disease can vary based on the specific valve affected and the severity of the condition. Common symptoms may include chest pain, shortness of breath, fatigue, and irregular heartbeats. The Diagnosis often involves a combination of physical examination, imaging tests (such as echocardiography), and sometimes cardiac catheterization. Treatment options may include medications to manage symptoms or, in more severe cases, surgical interventions like valve repair or replacement.

Unlocking Insights into Valvular Heart Disease

Clinical research plays a pivotal role in advancing our understanding of VHD. SCIRENT’s design and cardiovascular research expertise contributes to developing innovative treatment options. 

Current Challenges in Valvular Heart Disease Research involve:

  1. Understanding Disease Progression:

The natural progression of VHD, especially in asymptomatic individuals, is not fully understood. Research is needed to elucidate the factors influencing disease progression and identify opportunities for intervention. 

     2. Innovative Treatment Approaches:

Developing novel therapeutic approaches beyond traditional surgical interventions is a priority. Research aims to explore minimally invasive interventions to improve outcomes and reduce the need for invasive procedures.

    3. Patient Stratification:

Tailoring treatments to individual patients based on the specific characteristics of their valvular disease is an ongoing challenge. Precision medicine approaches are needed for effective patient stratification.

SCIRENT’s Contribution to Advancing Treatment Options for VHD

SCIRENT provides extensive experience and success stories in conducting cardiovascular research, specifically focusing on Valvular Heart Disease.

Discover the advantages of collaborating with SCIRENT for Valvular Heart Disease research. From personalized approaches to a commitment to data quality and regulatory compliance, find out how SCIRENT can be your strategic partner

What we offer:

Expertise in Cardiovascular Research

SCIRENT brings extensive cardiovascular research expertise, specifically focusing on VHD. Our dedicated teams of researchers are well-versed in the complexities of valvular diseases, ensuring a thorough understanding of the challenges at hand.

Cutting-Edge Methodologies

Utilizing state-of-the-art methodologies and technologies, SCIRENT conducts research that pushes the boundaries of knowledge in VHD. This includes advanced imaging techniques, genetic studies, and innovative trial designs.

Clinical Trial Design and Implementation

SCIRENT specializes in designing and implementing clinical trials focused on VHD. Through collaboration with pharmaceutical companies, researchers, and healthcare professionals, we contribute to developing new treatment modalities.

Data Quality and Regulatory Compliance

Ensuring the highest standards of data quality and regulatory compliance is a hallmark of SCIRENT's approach. This commitment is vital for the credibility and success of VHD research.

Patient-Centric Approach

SCIRENT recognizes the importance of a patient-centric approach in VHD research. By incorporating patient perspectives, we aim to address the unique challenges faced by individuals with valvular diseases, ultimately improving treatment outcomes.

Flexibility and Collaboration

SCIRENT offers flexibility in research design and fosters collaboration with diverse stakeholders. This ensures that the research conducted is comprehensive, considering the multifaceted nature of VHD.

At SCIRENT we are dedicated to pioneering research that contributes to the betterment of cardiovascular health. Explore collaboration opportunities with us and be part of the journey towards innovative solutions for Valvular Heart Disease.

Thank you. Your data was submitted successfully.

We will get in touch shortly.

Thank you for your application.

We will get in touch shortly.